49ers vs Colts head to head
The series is level at 1-1 across the 2 meetings Kelly holds since 2021, playoffs included. Against the closing spread the 49ers are 1-0 (1); over/under 1-0 (1). Last 2: 49ers 1-1 (2). Latest: San Francisco 49ers at Indianapolis Colts, Monday, December 22, 2025 at 8:15 PM ET.
Latest game
San Francisco 49ers at Indianapolis ColtsMonday, December 22, 2025 at 8:15 PM ET · 2025 week 16
Every meeting (2)
Row tabs and the Ask box filter on the engine's side; the record in the status line is counted for the rows in view.
Showing (2) of (2) · Meetings · Compared with the 2 meetings Kelly holds. In view: 49ers 1-1-0 (2), ATS 1-0-0 (1), O/U 1-0-0 (1), small sample
Data as of 2026-11-13 13:10 UTCSource: nflverse schedules and results (CC BY 4.0), changed by Kelly; closing lines: Kelly's consensus, else nflverse's published close from 1999
Series splits (7)
The series cut by site, season type, closing line, decade and the latest meetings, with the NFL average over the same seasons. Marked rates rest on fewer than 5 decided meetings.
Showing (7) of (7) · Splits · Compared with every meeting (2) and the NFL average
| Split | G | 49ers W-L-T | 49ers win % | SF pts/G | IND pts/G | 49ers margin/G | Points/G |
|---|---|---|---|---|---|---|---|
| Site | |||||||
| At San Francisco | 1 | 0-1-0 | 0% | 18 | 30 | -12 | 48 |
| At Indianapolis | 1 | 1-0-0 | 100% | 48 | 27 | 21 | 75 |
| Season type | |||||||
| Regular season | 2 | 1-1-0 | 50% | 33 | 28.5 | 4.5 | 61.5 |
| Closing line | |||||||
| 49ers favoured | 1 | 1-0-0 | 100% | 48 | 27 | 21 | 75 |
| No closing line | 1 | 0-1-0 | 0% | 18 | 30 | -12 | 48 |
| Decade | |||||||
| 2020s | 2 | 1-1-0 | 50% | 33 | 28.5 | 4.5 | 61.5 |
| Recent | |||||||
| Last 2 meetings | 2 | 1-1-0 | 50% | 33 | 28.5 | 4.5 | 61.5 |
| All meetings (2) | 2 | 1-1-0 | 50% | 33 | 28.5 | 4.5 | 61.5 |
| NFL average, 2021 to 2025 | 1,424 | — | — | 22.6 | 22.6 | — | 45.2 |
Data as of 2026-11-13 13:10 UTCSource: nflverse schedules and results (CC BY 4.0), changed by Kelly; closing lines: Kelly's consensus, else nflverse's published close from 1999
Streaks (4)
The longest runs in the series. Active streaks are still going.
Showing (4) of (4) · Streaks · Sorted by Meetings, high to low · Compared with every meeting Kelly holds (2)
| Streak of | Meetings | From | To | State | Out of |
|---|---|---|---|---|---|
| 49ers wins | 1 | 2025 W16 | 2025 W16 | Active | 2 |
| Colts wins | 1 | 2021 W7 | 2021 W7 | Ended | 2 |
| 49ers covers | 1 | 2025 W16 | 2025 W16 | Active | 1 |
| Overs | 1 | 2025 W16 | 2025 W16 | Active | 1 |
Data as of 2026-11-13 13:10 UTCSource: nflverse schedules and results (CC BY 4.0), changed by Kelly; closing lines: Kelly's consensus, else nflverse's published close from 1999
Postseason meetings (0)
No playoff meeting in the seasons Kelly holds since 2021.
Questions (4)
- What is the 49ers vs Colts head-to-head record?
- The series is level at 1-1 across the 2 meetings Kelly holds since 2021, playoffs included.
- What is the 49ers vs Colts record against the spread?
- The 49ers are 1-0-0 against the closing spread in the 1 meetings with a line; the Colts are 0-1-0.
- Do 49ers vs Colts games go over the total?
- 1 overs, 0 unders and 0 pushes against the closing total in the 1 meetings with one.
- Who won the last 49ers vs Colts game?
- The 49ers won 48-27 in Indianapolis on December 22, 2025.
Data as of 2026-11-13 13:10 UTC · 2 meetings Kelly holds since 2021 · results from nflverse (CC BY 4.0), changed by Kelly; closing lines from Kelly's consensus, else nflverse's published close