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49ers vs Cardinals head to head

The 49ers lead the series 10-5 across the 15 meetings Kelly holds since 2019, playoffs included. Against the closing spread the 49ers are 2-5 (7); over/under 3-4 (7). Last 10: 49ers 7-3 (10). Next: San Francisco 49ers at Arizona Cardinals, Sunday, January 10, 2027 at 1:00 PM ET.

Next game

San Francisco 49ers at Arizona CardinalsSunday, January 10, 2027 at 1:00 PM ET · 2026 week 18

Every meeting (15)

Row tabs and the Ask box filter on the engine's side; the record in the status line is counted for the rows in view.

Showing (15) of (15) · Meetings · Compared with the 15 meetings Kelly holds. In view: 49ers 10-5-0 (15), ATS 2-5-0 (7), O/U 3-4-0 (7)

GameDateTypeSiteWinnerScore49ers margin
2026 W32026-09-27Regular seasonSan Francisco49ersSF 36, ARI 306
2025 W112025-11-16Regular seasonArizona49ersSF 41, ARI 2219
2025 W32025-09-21Regular seasonSan Francisco49ersSF 16, ARI 151
2024 W182025-01-05Regular seasonArizonaCardinalsSF 24, ARI 47-23
2024 W52024-10-06Regular seasonSan FranciscoCardinalsSF 23, ARI 24-1
2023 W152023-12-17Regular seasonArizona49ersSF 45, ARI 2916
2023 W42023-10-01Regular seasonSan Francisco49ersSF 35, ARI 1619
2022 W182023-01-08Regular seasonSan Francisco49ersSF 38, ARI 1325
2022 W112022-11-21Regular seasonArizona49ersSF 38, ARI 1028
2021 W92021-11-07Regular seasonSan FranciscoCardinalsSF 17, ARI 31-14
2021 W52021-10-10Regular seasonArizonaCardinalsSF 10, ARI 17-7
2020 W162020-12-26Regular seasonArizona49ersSF 20, ARI 128
2020 W12020-09-13Regular seasonSan FranciscoCardinalsSF 20, ARI 24-4
2019 W112019-11-17Regular seasonSan Francisco49ersSF 36, ARI 2610
2019 W92019-10-31Regular seasonArizona49ersSF 28, ARI 253
Total (15)—————86
Per meeting—————5.7

Data as of 2026-11-14 16:17 UTCSource: nflverse schedules and results (CC BY 4.0), changed by Kelly; closing lines: Kelly's consensus, else nflverse's published close from 1999

Series splits (9)

The series cut by site, season type, closing line, decade and the latest meetings, with the NFL average over the same seasons. Marked rates rest on fewer than 5 decided meetings.

Showing (9) of (9) · Splits · Compared with every meeting (15) and the NFL average

SplitG49ers W-L-T49ers win %SF pts/GARI pts/G49ers margin/GPoints/G
Site
At San Francisco85-3-062.5%27.622.45.250
At Arizona75-2-071.4%29.423.16.352.6
Season type
Regular season1510-5-066.7%28.522.75.751.2
Closing line
49ers favoured53-2-060%27.2234.250.2
Cardinals favoured21-1-050%2229.5-7.551.5
No closing line86-2-075%30.920.91051.8
Decade
2020s138-5-061.5%27.922.35.650.2
2010s22-0-0100%3225.56.557.5
Recent
Last 10 meetings107-3-070%31.323.77.655
All meetings (15)1510-5-066.7%28.522.75.751.2
NFL average, 2019 to 20262,097——22.922.9—45.8

Data as of 2026-11-14 16:17 UTCSource: nflverse schedules and results (CC BY 4.0), changed by Kelly; closing lines: Kelly's consensus, else nflverse's published close from 1999

Streaks (18)

The longest runs in the series. Active streaks are still going.

Showing (18) of (18) · Streaks · Sorted by Meetings, high to low · Compared with every meeting Kelly holds (15)

Streak ofMeetingsFromToStateOut of
49ers wins42022 W112023 W15Ended15
49ers wins32025 W32026 W3Active15
Cardinals covers32024 W52025 W3Ended7
Unders32020 W12024 W5Ended7
49ers wins22019 W92019 W11Ended15
Cardinals wins22024 W52024 W18Ended15
Cardinals wins22021 W52021 W9Ended15
Home team wins22024 W182025 W3Ended15
Home team wins22022 W182023 W4Ended15
Overs22025 W112026 W3Active7
Cardinals wins12020 W12020 W1Ended15
Home team wins12026 W32026 W3Active15
49ers covers12025 W112025 W11Ended7
49ers covers12020 W162020 W16Ended7
Cardinals covers12026 W32026 W3Active7
Cardinals covers12020 W12020 W1Ended7
Overs12024 W182024 W18Ended7
Unders12025 W32025 W3Ended7

Data as of 2026-11-14 16:17 UTCSource: nflverse schedules and results (CC BY 4.0), changed by Kelly; closing lines: Kelly's consensus, else nflverse's published close from 1999

Postseason meetings (0)

No playoff meeting in the seasons Kelly holds since 2019.

Questions (5)

What is the 49ers vs Cardinals head-to-head record?
The 49ers lead the series 10-5 across the 15 meetings Kelly holds since 2019, playoffs included.
What is the 49ers vs Cardinals record against the spread?
The 49ers are 2-5-0 against the closing spread in the 7 meetings with a line; the Cardinals are 5-2-0.
Do 49ers vs Cardinals games go over the total?
3 overs, 4 unders and 0 pushes against the closing total in the 7 meetings with one.
Who won the last 49ers vs Cardinals game?
The 49ers won 36-30 in San Francisco on September 27, 2026.
When do the 49ers and Cardinals play next?
San Francisco 49ers at Arizona Cardinals, Sunday, January 10, 2027, at 1:00 PM ET.

Data as of 2026-11-14 16:17 UTC · 15 meetings Kelly holds since 2019 · results from nflverse (CC BY 4.0), changed by Kelly; closing lines from Kelly's consensus, else nflverse's published close